Stronger together.
Collaboration will enable the consortium to pool resources and expertise while giving patients access to treatments and support without having to change where they receive care.
.avif)
We’re proud to include the vast majority of children’s hospitals across North Carolina and South Carolina.
By partnering with these esteemed hospitals, we're able to help enhance patient care and support the critical work of medical professionals who make a difference in children's lives every day.
A coordinated network of care
Together, we’ve built an extensive network of clinicians, researchers, specialists and laboratories, ensuring cutting-edge research, innovation and care are at the forefront of pediatric cancer treatment.
Physicians


East Carolina University (ECU)

East Carolina University (ECU)
I am a Pediatric Hematologist Oncologist at East Carolina University, serving twenty-nine counties east of I-95. Our team provides care for children, adolescents, and young adults with cancer, sickle cell disease, and bleeding and clotting disorders, as well as patients with benign hematology, off therapy/late effects, bone marrow failure syndromes, vascular anomalies, and cancer predisposition syndromes. We participate in Children's Oncology Group (COG) clinical trials and additional clinical and pharmaceutical trials focusing on sickle cell and bleeding disorders. As a generalist, I care for all children with blood and cancer disorders and am the primary clinician for children and young adults with brain and CNS tumors. I also provide hospice care for palliative neuro-oncology patients through collaboration with local pediatric hospice entities. My clinical interests include general pediatric oncology, vascular malformations, bone marrow failure syndromes, cancer predisposition syndromes, ITP, neuro-oncology, and diagnostic dilemmas. With nearly 13 years of experience since completing fellowship, I am dedicated to providing excellent care and helping to advance the field of Pediatric Hematology/Oncology.


Novant Health Hemby Children's Hospital

Novant Health Hemby Children's Hospital
I am a pediatric oncologist with a MSc in clinical research. My previous research has been in leukemia/lymphoma and supportive care. I previously studied the efficacy of IVIG supplementation in preventing infection-related outcomes in children with B-ALL. My current clinical practice involves all of hematology and oncology. My research interests are in supportive care, palliative care, and collaborative efforts in treatment trials.


Prisma Health Midlands

Prisma Health Midlands
I am a pediatric oncologist and physician scientist focused on clinical outcomes research. I care for children with leukemia and lymphoma and also have a passion for survivorship and supporting our patients as they become young adults. My clinical research is funded through St. Baldricks and Hyundai Hope on Wheels and focuses on how social determinants of health mediate adverse outcomes for our patients upfront and in survivorship.


Medical University of South Carolina (MUSC)

Medical University of South Carolina (MUSC)
Dr. Hudspeth graduated as valedictorian from the MUSC College of Medicine in 1999. She completed her pediatrics residency at Johns Hopkins Hospital and was selected as a chief resident for the Harriet Lane Service. She completed her pediatric hematology/oncology fellowship at Johns Hopkins Hospital/National Cancer Institute.
After starting her faculty career at Johns Hopkins, she returned to MUSC in 2007 with the goal of expanding the pediatric BMT program. Her clinical research focus includes all aspects of HSCT, and she served as a protocol writer for the prospective PTCTC multi-center trial utilizing PT-Cy for pediatric patients undergoing haploidentical BMT with myeloablative prep regimens.
She is the secretary/treasurer for the American Society of Pediatric Hematology/Oncology and on the BMT-CTN Steering Committee. She is the Medical Director for the Adult and Pediatric BMT and Cellular Therapy Program at MUSC, which was designated by CIBMTR in 2024 as an overperforming center for allogeneic transplant outcomes 2020-2022.


UNC Health Children's Hospital

UNC Health Children's Hospital
My primary area of clinical interest is pediatric neuro-oncology, but I take care of children with all cancers and blood disorders. I am a translational researcher and clinical trialist. My primary research interests are in better elucidating the complex mechanisms of oncogenesis, invasion, and immune escape in low and high-grade pediatric brain tumors, which together are now the leading cause of cancer-related death in children. My ultimate goal is to help develop new therapeutic strategies for pediatric brain tumors that are more effective and less toxic.


Medical University of South Carolina (MUSC)

Medical University of South Carolina (MUSC)
Dr. Jacqueline Kraveka is a Professor of Pediatrics and a Pediatric Hematologist-Oncologist at the Medical University of South Carolina (MUSC) in Charleston, SC. Born in Velasco, Cuba, she emigrated to the United States at age four. She earned her undergraduate degree from Columbia University in 1989 and her medical degree from Nova Southeastern University College of Osteopathic Medicine in 1994. After completing her pediatrics residency at Miami Children's Hospital in 1997, she pursued a fellowship in pediatric hematology-oncology at MUSC, where she has been on staff since 2000. Dr. Kraveka specializes in pediatric oncology, with a focus on neuroblastoma, pediatric sarcomas, precision medicine, and clinical trial development. She plays a key role in pediatric cancer research as a member of the Executive Board and Scientific Committee for the Beat Childhood Cancer Research Consortium (BCC) and serves as the Institutional Principal Investigator for Children's Oncology Group and BCC clinical trials at MUSC. Her laboratory research focuses on developing innovative therapies, including sphingolipid-mediated treatments, to improve outcomes for children with cancer.


Atrium Health Wake Forest Baptist

Atrium Health Wake Forest Baptist
I am a general pediatric hematologist/oncologist with experience in all types of pediatric cancer and blood diseases as well as vascular anomalies (such as hemangiomas) and histiocytosis. While I am first and foremost a clinician, I also enjoy teaching, research, and administration. My research has focused on leukemia, supportive care, fertility preservation, integrative therapies, and vascular anomalies. Outside of work, I enjoy golf, running, reading, travel, and spending time with my family.


Atrium Health Levine Children's Hospital

Atrium Health Levine Children's Hospital
Jennifer Pope is the Director Supportive Medicine within Levine Children's Hospital Cancer and Blood Disorders Program. In that role, she oversees and participates in the multidisciplinary teams caring for children and young adults with cancer, complex blood diseases, and cancer survivors. As an integrative medicine physician, her focus is on whole person/whole family care and support. Her research interests include integrative topics including exercise, sleep, and advanced symptom management with mind/body therapies.


Wake Forest University School of Medicine

Wake Forest University School of Medicine
I am an Assistant Professor of Pediatrics at Wake Forest University School of Medicine in the Section of Hematology Oncology. My research focuses on cancer-related financial hardship and barriers to linguistically and culturally tailored care in diverse families of children and adolescents with cancer. Through the Children's Oncology Group (COG) study ACCL20N1CD, I am currently investigating financial distress in parents of children with acute lymphoblastic leukemia (ALL) treated at COG NCI Community Oncology Research Program (NCORP) practices. I am also actively involved in multi-institutional efforts to improve cancer care delivery and access to clinical trials through the COG Cancer Care Delivery Research Committee, COG Language Equity Working Group, and the COG Diversity and Health Disparities Committee.


Atrium Health Levine Children's Hospital

Atrium Health Levine Children's Hospital
I direct our Isabella Santos Foundation rare and solid tumor program at Levine Children's Hospital. My area of interest is in advancing basic/translational science and early phase clinical trial opportunities for pediatric sarcoma patients.


UNC Chapel Hill

UNC Chapel Hill
Through my combined training in internal medicine and pediatrics, and subsequent training in pediatric hematology/oncology, I have developed both research and clinical interests in improving survivorship care and outcomes for children, adolescents, and young adults (AYAs) with cancer. As an Associate Professor of Pediatrics and the Medical Director for the Lineberger Adolescent and Young Adult (AYA) Cancer Program at the University of North Carolina at Chapel Hill, I lead clinical programs (including the UNC AYA Cancer Survivorship Clinic and the UNC Outpatient Hematology-Oncology Clinic) and initiatives to improve survivorship care and clinical research. My current work examines accelerated aging in childhood and AYA survivors. We use measures of frailty (phenotype and index), sarcopenia (bioelectrical impedance and CT scans), physical function (timed up and go, grip strength), and biological biomarkers (p16INK4a and epigenetic clocks) to describe the impact of cancer and its treatment on the aging process in survivors.


Duke Children's Hospital and Health Center

Duke Children's Hospital and Health Center
I am a pediatric oncologist at Duke, where I run our neuroblastoma, survivorship, and pediatric oncology clinical research programs.


Atrium Health Levine Children's Hospital

Atrium Health Levine Children's Hospital
Erin Trovillion, MD, is a Pediatric Hematologist/Oncologist. She completed her pediatric residency and fellowship training at the University of California San Diego Rady Children's Hospital, solidifying her foundation in pediatric oncology. In 2020, Dr. Trovillion joined the Levine Children's Pediatric Cancer and Blood Disorders team specializing in sarcoma as part of the Isabella Santos Foundation Rare and Solid Tumor Program. Driven by a passion for enhancing patient care, Dr. Trovillion spearheaded the creation of the Pediatric Oncofertility Team, which has evolved into a multidisciplinary program offering consultations to pediatric oncology patients of all ages undergoing gonadotoxic treatments. Her commitment to comprehensive care now extends to her role as the Medical Director of the Adolescent and Young Adult (AYA) comprehensive program at Atrium Health Levine Cancer, reshaping cancer care for adolescents and young adults by working collaboratively to leverage resources and expertise across the enterprise to improve patient outcomes. In addition to her clinical duties, Dr. Trovillion is an active member of the Pediatric Hematology/Oncology Blood Quality Improvement Committee and the Best Practice Committee striving to elevate standards of care for all patients.


East Carolina University (ECU)

East Carolina University (ECU)
Personally, I am a wife to a fearless stay-at-home dad and a mother to 5 amazing children. Professionally, I am a general pediatric hematologist/oncologist, but my focus is on pediatric oncology. I am the local PI for COG and the director of the oncology survivorship clinic. My patients deserve the best care possible. My job is to give them my all and never give up. I gain inspiration and hope in return.
PhDs


Medical University of South Carolina (MUSC)

Medical University of South Carolina (MUSC)
Dr. Blanco has dedicated her career to understanding and treating medulloblastoma, the most common malignant brain tumor in children. She earned her PhD in Neurosciences at the University of Oviedo (Spain) and pursued further training at Columbia University and the University of Miami, specializing in developmental signaling and cancer. During her second postdoctoral fellowship, she combined neuroscience and cancer signaling to investigate pediatric brain tumors.Now an independent investigator at the NCI-designated Hollings Cancer Center and the Darby Children's Research Institute at MUSC, Dr. Blanco focuses on medulloblastoma relapse and metastatic disease. Her studies include recent publications in Science Advances and Journal of Clinical Investigation as a corresponding author. She has received prestigious awards, including the Alex's Lemonade Stand Foundation "A" Award, the V Foundation Scholar Award, a Rally Foundation Career Development Award, and an NINDS K01 Award. Committed to translating research into actionable treatments, she strives to improve outcomes for children with brain tumors.


Duke University

Duke University
I received my doctoral degree from Florida International University in Miami, FL and was an American Cancer Society postdoctoral fellow at Duke University. I am currently an Assistant Professor in the Department of Medicine at Duke University. I serve as the Director of Research for the Duke Cancer Institute Comparative Oncology Group and as Director of the Duke University Marine Laboratory Scholars in Marine Medicine Program. Our research team uses evolutionary and ecology paradigms to understand molecular adaptations to extreme environments. Our work spans diverse topics, such as the evolutionary pressures faced by cancer cells during drug treatment and metastatic spread, the molecular adaptations of whales and other marine mammals to low oxygen conditions, and the evolution of microbes to use plastic as a nutrient source. In addition to my scholarly activities, I am passionately involved in training and education, leading multiple outreach and research training programs for high school students and undergraduates in an effort to enhance opportunities in STEM careers.
Laboratories

Our focus is the field of Comparative Oncology - the study of cancer across different species. The overall hypothesis is that by understanding the standard drivers of specific cancer types from one species to another, we can learn "what really matters" about that type of cancer. We study sarcomas, which are rare in people, but common in dogs. Dr. Eward's ongoing work with both dogs and people due to his dual degree background as both a veterinarian and a physician helps us to develop a deeper understanding of how these cancers work.

Dr. Kraveka's laboratory research focuses on sphingolipid mediated therapies in pediatric cancers. The long-term goals of her research are to develop more effective treatments for children with cancer.



Our research is aimed at finding more effective therapeutics for the most common form of pediatric brain tumor: medulloblastoma. Due to the poor survival numbers that children with relapsed medulloblastoma have, we intend to uncover the signaling mechanisms allowing these tumors to re-grow after treatment. BY using bioinformatic analyses, followed by series of ex vivo and in vivo studies, we hope to find treatments ensuring a long-term and stable tumor remission. Moreover, the targeted nature of our treatment approaches should show fewer co-morbidities in pediatric patients than current adjuvant chemotherapeutics targeting any cell in proliferation.



The treatment of relapsed and refractory pediatric sarcomas has shown little progress in the past 30 years. Patients whose disease recurs after front line treatment face dismal prognoses and new and more effective treatments are desperately needed for these children, teens, and young adults. To achieve improved patient outcomes, a deeper understanding of the molecular mechanisms involved in relapse and metastasis is imperative.
To accomplish this mission, the Levine Children’s researchers are employing an exciting approach. This innovative study utilizes mass cytometry (CyTOF) to investigate the effects of targeted therapies on tumor microenvironment and on distinct subpopulations of cells within Ewing sarcoma tumors. Subpopulations of tumor cells are known to play unique roles in disease progression, metastasis, and therapy resistance, demonstrating the need to characterize how a treatment may differentially affect these various groups of cells. The use of CyTOF allows for these effects to be studied at the single cell level, more fully describing the differential response to treatment throughout the tumor. The knowledge being gained from this study will be applied to the development of clinical trials, providing new treatment strategies with the goal of improving outcomes for Ewing sarcoma patients.


Atrium Health Levine Children's Hospital

Atrium Health Levine Children's Hospital
I am an attending in Pediatric Stem Cell Transplant and Cellular Therapies at Atrium Health Levine Children's Hospital, an investigator in the Levine Children's Pediatric Oncology Research Laboratory, and an Assistant Professor at Wake Forest School of Medicine. My laboratory and clinical research is focused on advancement of cellular immunotherapies for pediatric hematologic and solid malignancies. My areas of current basic and clinical research include stem cell transplantation for malignancies, CAR T-cell and other engineered immunotherapies, and dissection of tumor microenvironments using mass cytometry (CyTOF). I currently also serve as chair of the Scientific Review Committee for the Department of Pediatrics at Levine Children's Hospital. I received my MD/PhD through the MSTP program at the University of Michigan, my residency in Pediatrics at Washington University in St. Louis / St. Louis Children's, and my fellowship in Pediatric Hematology/Oncology at the joint Johns Hopkins / NCI @ NIH. I was a faculty member in Pediatric BMT at Hopkins before joining Levine Children's in 2016.


Duke University

Duke University
I am an MD-trained research scientist working at Duke since 2022, focusing on in vitro 3D cancer models. These models, known as organoids, more accurately replicate cancer biology compared to traditional cell lines. My research aims to uncover mechanisms of drug resistance in osteosarcoma, a major challenge in cancer therapy that contributes to treatment failure and metastasis. By leveraging advanced models, we strive to gain deeper insights into resistance pathways and identify potential therapeutic strategies.
Executive Committee


Prisma Health Midlands

Prisma Health Midlands
Stuart Cramer, DO, joined Prisma Health in 2017 as the medical director of the Children's Center for Cancer and Blood Disorders. Originally from Florida, he received his medical degree at Nova Southeastern University College of Osteopathic Medicine and completed his pediatric hematology/oncology fellowship at the University of Alabama Children's Hospital in Birmingham, where he was the director of developmental therapeutics.As part of his honors thesis while in college, Dr. Cramer pursued three years of scientific research, which provoked his appreciation of merging basic science with clinical medicine. His fellowship training solidified his interest in cancer cell biology, and afforded him the opportunity to expand his research experience focusing on novel therapeutics. With his research background, he has developed a broad knowledge of drug resistance within pediatric solid tumors and the role of novel therapeutics in the treatment of pediatric solid tumors. Cramer's current focus is on developing a therapeutics program based in Columbia, enabling pediatric patients access to novel therapies developed both nationally and locally.


UNC Chapel Hill

UNC Chapel Hill
I am a physician-scientist. My clinical focus is on childhood solid tumors, such as sarcomas. My lab focuses on the way that DNA and proteins interact to foster the development of cancer. We use experimental and computational approaches to understand the mechanisms of cancer development and identify new treatments.


Atrium Health Levine Children's Hospital

Atrium Health Levine Children's Hospital
I focus my clinical work on solid tumors with a focus on Neuroblastoma. I have a keen interest in drug development and clinical trials. I have been a study chair for 2 national trials and working with our lab currently in development of new drug combinations. I appreciate the mentors that have helped me along the way, and I hope I can give back in the same way. I have also been division chief since 2015.


Prisma Health Upstate

Prisma Health Upstate
I am a pediatric hematologist oncologist and have been living and working in Greenville, SC, for 10 years. I have a strong clinical interest in adolescent and young adult oncology and leukemias and lymphomas.


Duke Children's Hospital and Health Center

Duke Children's Hospital and Health Center
I am a pediatric oncologist with a focus on solid tumors, especially sarcoma. As a clinical researcher, I have helped develop new regimens for these patients, as well as to further our understanding regarding sarcoma biology, treatment resistance, supportive care, and response assessment.
Scientific Review Committee


Novant Health Hemby Children's Hospital

Novant Health Hemby Children's Hospital
I am the Medical Director of the St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital. I studied Biology and History at Williams College before obtaining my medical degree from the Wake Forest University School of Medicine. I then completed my Pediatrics Residency and Pediatric Hematology Oncology fellowship at the University of North Carolina at Chapel Hill. I have been at Novant Health since 2008. I have served as the site principal investigator for Children's Oncology Group as well as collaborative clinical trials in leukemia and lymphoma. Additional interests include integrative medicine supportive care.


Prisma Health Upstate

Prisma Health Upstate
I am a pediatric hematology oncology physician at Prisma Health Upstate in Greenville, SC with interest in leukemias, lymphomas, and non-CNS solid tumors. I also have training in clinical pharmacology with experience in spearheading pilot studies. My passion is using my clinical pharmacology training specifically pharmacogenomics to enhance precision medicine for pediatric oncology patients.


Medical University of South Carolina (MUSC)

Medical University of South Carolina (MUSC)
I am a pediatric oncologist with special interest in solid tumor and survivorship. I was born and raised in Romania where I completed medical school. Pediatric residency was completed at Geisinger Medical Center in Danville, PA followed Pediatric hematology oncology fellowship at MUSC in Charleston SC. I now run the pediatric survivorship clinic at MUSC.


Duke University

Duke University
I am a pediatric oncologist and physician-scientist with a focus in pediatric and young adult sarcoma. My research specifically focuses in osteosarcoma, the most common bone tumor in children and adolescents and one which is characterized by high rates of chemotherapy resistance. The overall goal of my research is to study chemotherapy resistance in a novel way, through examining how mitochondria in osteosarcoma cells adapt both to the stress imposed by chemotherapy exposure and to the relaxation of stress after chemotherapy is complete. In doing so, we aim to identify and target vulnerabilities that emerge as a direct consequence of chemotherapy, thereby eradicating therapy-resistant cells to improve patient survival.
Administrative Team


Administrative Director

Administrative Director


Consortium Research Operational Lead

Consortium Research Operational Lead


Biostatistician

Biostatistician
I am an Assistant Professor in the Department of Biostatistics and Data Science at the Wake Forest University School of Medicine and a member of the Comprehensive Cancer Center, Center for Artificial Intelligence Research, Center for Prevention Science in Child and Family Health, and Center for Remote Health Monitoring. As the Director of Biostatistics for ARISE, I oversee all biostatistical components of ARISE studies. I earned my PhD in Biostatistics from the Medical University of South Carolina in 2018. My expertise focuses on the design, conduct, and analysis of clinical trials (with an emphasis on early-phase dose-finding studies) and the development of clinical prediction models using machine learning. Much of my cancer research involves analyzing comprehensive adverse event (AE) data to better understand patient toxicity burden and improve trial design. Beyond trial methodology, I have additional expertise in longitudinal and clustered data analysis, EHR data analysis, Bayesian modeling, survival analysis, and causal mediation. Outside of work, I enjoy spending time with my wife (Jaime), our two kids (Lennie and Avi-Warren), and our Golden Retriever (Zelda), as well as following baseball (Atlanta Braves), F1 racing (Ferrari), and college football.


Founder and Executive Director

Founder and Executive Director
I focus my clinical work on solid tumors with a focus on Neuroblastoma. I have a keen interest in drug development and clinical trials. I have been a study chair for 2 national trials and working with our lab currently in development of new drug combinations. I appreciate the mentors that have helped me along the way, and I hope I can give back in the same way. I have also been division chief since 2015.


Regulatory Consultant

Regulatory Consultant
Make a difference today.
Your support fuels hope, innovation and care for pediatric cancer patients. Join us in making a lasting impact.
